Subcellular Localization of “In in Human and Rabbit Platelets
نویسندگان
چکیده
In order to examine the subcellular distribution of 111In in “In-oxine-labeled human and rabbit platelets. we employed a hypothetical grain technique of EM autoradiograph analysis. The results indicated that in the rabbit ‘11In was concentrated within the platelet dense bodies. particularly when the platelets had been labeled in a plasma-free system. Under comparable conditions of labeling. human platelets appeared to accumulate almost all the radiolabel within the cytosol. Using inhibitors of 5-hy-
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